Genetic Definition and Phenotypic Determinants of Human Ovarian Carcinomas
Abstract
Ovarian cancer is the fourth leading cause of cancer-related death in U.S. women. This program project approaches the ovarian cancer problem by (1) establishing a human ovarian tissue and clinical data base core facility to support the proposed projects and future investigations, (2) identifying genes which are differentially expressed in ovarian cancers and thereby discovering biomarkers for early detection, (3) studying ovarian tumorigenesis in ovarian tissues obtained from germline BRCA1 mutation carrier to better understand the interaction between mutational inactivation of BRCA1, the cellular caretaker gene and p53, the cellular gatekeeper gene, and (4) developing a genetically defined mouse model of epithelial ovarian cancer. To date, the ovarian tissue core has banked over 260 surgical specimens and provided sufficient resources for the ongoing projects and other collaborative research on ovarian cancer etiology. Representational difference analysis was used to identify 160 genes specific for normal ovarian epithelium and 95 genes specific for ovarian cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2002
- Accession Number
- ADA412766
Entities
People
- Beth Karlan
Organizations
- University of California, Los Angeles