Phosphoinositide 3-Kinase/AKT1 Pathway and Human Ovarian Cancer

Abstract

We have previously shown significantly increased Akt kinase activity and AKT2 protein level in primary ovarian carcinoma Recently, we have demonstrated that activation and overexpression of Akt contribute to chemoresistance by (1) phosphorylation of ASK1 leading to inhibition of JNK and p38 kinase activity, (2) induction of XIAP through a interactionlphosphorylation mechanism and (3) phosphorylation of p21 leading to G2/M progression.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2002
Accession Number
ADA412768

Entities

People

  • Jin Q. Cheng

Organizations

  • University of South Florida

Tags

DTIC Thesaurus Topics

  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Epithelial Cells
  • Genetics
  • Health Services
  • Programmed Cell Death
  • Proteins
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

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  • Molecular Biology and Genetics