A New Perspective on DCIS Using MRI: Correlation of Tumor and Vessel Proliferation with MR Signal Enhancement
Abstract
The purpose of this study is to correlate density of contrast enhancement on breast MRI images with pathology characteristics and markers of proliferation and angiogenesis in women with ductal carcinoma in situ (DCIS) of the breast The specific aims of the study are two-fold (1) We will first develop a novel method for characterizing DCIS lesions based on cellular proliferative activity and angiogenesis within the tumor and surrounding vascular endothelium Using immunohistochemical techniques, we will determine the relationship between proliferation and angiogenic activity in the range of DCIS detected. (2) Secondly, we will correlate the proliferative and angiogenic profile with MRI characteristics in order to determine whether MR can predict the biological characteristics of DCIS. Thus MR could potentially serve as a surrogate marker of biological behavior These two aims will lead to a better understanding of the basis and timing for transformation of DCIS which would help us to find more optimal ways to treat DCIS and help us to treat invasive breast cancer and develop strategies for prevention.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2002
- Accession Number
- ADA412770
Entities
People
- Laura J. Esserman
- Nola Hylton
Organizations
- University of California, San Francisco