TGF-Beta Regulation of the Mammary Radiation Response

Abstract

Transforming growth factor beta 1 (TGF beta 1) orchestrates the response of different cell types to injury via regulation of proliferation, apoptosis and ECM composition. Previously we discovered that TGF beta 1 is rapidly activated in mammary gland following radiation. Because TGF-beta 1 is implicated in regulation of proliferation and apoptosis, we investigated whether the activation of TGF-beta 1 contributes to the cell fate decisions in response to radiation. We found that radiation-induced apoptosis and cycle cell arrest are absent in adult mammary epithelium and embryonic liver and epidermis when TGF-beta 1 is compromised.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2002
Accession Number
ADA412771

Entities

People

  • Maria J. Pajares

Organizations

  • University of California, Berkeley

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antibodies
  • Antigens
  • Biological Sciences
  • Biomedical Research
  • Cell Physiological Processes
  • Cell Physiology
  • Chemistry
  • Epithelial Cells
  • Epithelium
  • Growth Factors
  • Ionizing Radiation
  • Mammary Glands
  • Peptide Growth Factors
  • Proteins
  • Radiation
  • Tissue Extracts
  • Tissues

Fields of Study

  • Medicine

Readers

  • Molecular Biology and Genetics