Interactions of Subsymptomatic Doses of Sarin With Pyridostigmine - Neurochemical, Behavioral, and Physiological Effects
Abstract
This report describes the effects of treatment with low levels of the cholinesterase (ChE) inhibitors Sarin (0.5 LDSO s.c. 3 times weekly) and pyridostigmine bromide (PB, 80 mg/L in drinking water) alone or in combination for 3 weeks as compared with untreated controls. At 2, 4 and 16 weeks after exposure, we studied the brain regional levels of glucose utilization (rCGU), as well as electroencephalographic activity, heart rate and locomotor activity with a telemetry system, on an hourly basis throughout the day, during seven-day periods. Statistical parametric maps of cerebral cortex rCGU obtained were compared with similar maps of cortical cerebral blood flow (rCBF) obtained during the previous year. The slope relating rCBF to rCGU in cerebral cortex was enhanced by sarin and depressed by sarin + PB four weeks after treatment. The analysis of cardiovascular regulation indicated significant reduction of heart rate and enhanced heart rate variability during PB treatment that recovered partially one week after treatment. Sarin (4 weeks) and PB (4 and 16 weeks) also showed enhanced HR variability. Sarin induced enhanced heart rate variability at all times after treatment. In conclusion, the changes in rCBF/rCGU coupling observed 4 weeks after sarin are consistent with residual cholinesterase inhibition in vascular compartments. The changes in heart rate variability deserve further exploration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2003
- Accession Number
- ADA412773
Entities
People
- Donald J. Jenden
- Oscar U. Scremin
- Tsung-Ming Shih