The Role of S100A7/RANBPM Interaction in Human Breast Cancer
Abstract
The purpose of this study is to determine the role of psoriasin (SlOOA7)in breast cancer. We began by identifying potential interacting partners for psoriasin and then examined the importance of these interactions in breast cells. We first studied the interaction of psoriasin with RanBPM and although we could confirm their interaction invitro, the same could not be said for invivo. RanBPM mRNA expression was found to be much higher in cancer cell lines than fibroblast and normal epithelia cell lines. In a cohort of 64 breast tumors RanBPM expression was found not to correlate with any parameter, while psoriasin was found to be highly associated with Estrogen Receptor negativity and inflammation. We found that transcription of RanBPM could be induced in primary peripheral lymphocytes by stimulating with PHA. Further characterization of the RanBPM-psoriasin interaction may lead to a better understanding of the process of invasion.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2002
- Accession Number
- ADA412819
Entities
People
- Ethan Emberley
- Peter H. Watson
Organizations
- University of Manitoba