Vasopressin Regulation and Renal Fluid and Electrolyte Handling in Rat Model of Acute and Chronic Alcohol Exposure
Abstract
We have previously shown that after effects of short term alcohol exposure cause rats to have an increased water diuresis in response to a water load whereas after long term alcohol exposure, rats exhibit an impaired ability to excrete a water load. Our latest data indicate that in a 4-week withdrawal phase from chronic alcohol exposure, water excretion impairment begins to return towards control levels. The up- and down-regulation of renal vasopressin V2 receptors appear to be behind differentially altered renal function in different phases of alcohol exposure. Prolonged diuresis during the acute phase of alcohol exposure is associated with a decrease in V2 receptor mRNA and a down-regulation of V2 receptors. During chronic alcohol exposure, renal V2 receptor mRNA is up-regulated, indicating that increased synthesis of V2 receptors causes increased renal efficacy of vasopressin despite similar circulating vasopressin levels between alcohol-exposed and control rats. During the withdrawal phase, V2 receptor mRNA returns toward normal levels, demonstrating that chronic alcohol-induced impairment of renal water excretion is reversible. Results suggest that alcohol-induced changes in renal responsiveness to vasopressin causes the pattern of diuresis, impaired water excretion, and recovery in the different phases of alcohol exposure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2002
- Accession Number
- ADA412845
Entities
People
- Catherine F. T. Uyehara
Organizations
- Tripler Army Medical Center