Liposomal Sphingolipids to Target Breast Adenocarcinoma Apoptosis
Abstract
Over-expression of HER-2/neu has been linked to poorer prognosis and reduced survival in breast cancer patients The basis for this association is likely multifactorial and includes therapeutic resistance, such as resistance to Taxol (paclitaxel), widely used in many chemotherapeutic regimens for this disease We have recently observed that certain sphingolipids (e.g., dimethyl-sphingosune), either as free lipids or as constituents of liposomes, induce apoptosis in vitro in tumor cells despite the over-expression of HER-2/neu, P-gp-170 and other resistance mechanisms relevant to breast cancer. The purpose of the current studies was to translate the formulation and toxicity studies of liposomal-dimethyl-sphingosine (L-DMSP) conducted in the previous years to initial proof-of- principle studies in nude mouse/human HER-2/neu over-expressing breast adenocarcinoma models Investigations leading to and pertinent to Aims 5 (efficacy studies) were the main focus We present herein evaluation of the anti-tumor efficacy of L-DMSP in the human HER-2/neu over-expressing breast adenocarcinoma orthotopic xenograft model, MDA-MB-361.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2002
- Accession Number
- ADA412990
Entities
People
- Jim Klostergaard
Organizations
- The University of Texas MD Anderson Cancer Center