Isolation of Motile Tumor Cells from Live Breast Tumors
Abstract
Metastasis represents the major cause of mortality in breast cancer patients Components of the metastatic process can include growth at the primary site, attraction of new blood vessels to the primary tumor, dissemination of tumor cells in the surrounding connective tissue, intravasation and distribution of tumor cells in the blood stream or lymphatics, spread to axillary lymph nodes, extravasation across blood vessel walls and into tissue parenchyma at a secondary site, and growth at the secondary site. These components encompass and rely upon a large number of cellular functions. Cell motility is believed to be important for dissemination of cells from the primary tumor, intravasation, and extravasation. Proof that the motility of tumor cells is a key component in metastasis would be a major advance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2002
- Accession Number
- ADA412991
Entities
People
- John Condeelis
Organizations
- Albert Einstein College of Medicine