Susceptibility of BRCA2 Heterozygous Normal Mammary Epithelial Cells to Radiation Induced Transformation
Abstract
Breast cancer is by far the most frequently diagnosed cancer in women Each year over 186,000 new cases and 46,000 deaths are reported in United State alone(1). Germ-line mutations in the breast cancer susceptibility genes BRCA2 and BRCA1 confer susceptibility to familial early-onset breast and ovarian cancers (2-6) So far very few somatic mutations of BRCA2 have been found in sporadic breast cancer However, loss of heterozygosity at the BRCA2 locus has been observed in 30-40% of sporadic breast tumors (7-12), which suggests that loss of BRCA2 gene may also be associated with sporadic breast and ovarian cancers It has been noted that the genomic region of BRCAl and BRCA2 genes contains very high densities of repetitive DNA elements, which can lead to high genomic instability (13) This distinctive genomic instability might contribute to the inactivation of in sporadic breast or ovarian cancer
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2002
- Accession Number
- ADA412997
Entities
People
- Quingshen Gao