NF1 - Regulated Adenylyl Cyclase/cAMP Pathways
Abstract
This project takes Drosophila NF1 mutants and mouse Nf1 mutants as models to investigate NF1-dependent regulation of the cAMP pathway. The study is intended to expand the knowledge of the genes that contribute to NF beyond the GAP-related domain in NF 1 In the last year, our work has been mainly focused on two aspects. First, the effort has been devoted to establish biochemically how G-protein-dependent activation of adenylyl cyclase (AC) activity is regulated by NF1 in Drosophila. Second, whether a similar biochemical regulation of AC activity can be identified in vertebrates These studies have led to a finding that G-protein-dependent activation of AC consists of two components: one is classically described NF 1-independent one while the other is NF 1-dependent Accumulated evidence from our last year's effort support that a similar NF-dependent mechanism can be observed in vertebrates We are continuing to pursue a molecular understanding of this regulation and whether this pathway contributes to pathogenesis of NF1.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2002
- Accession Number
- ADA413041
Entities
People
- Zhong Yi
Organizations
- Cold Spring Harbor Laboratory