Prostate Cancer Cell Growth: Role of Neurotensin in Mediating Effect of Dietary Fat and Mechanism of Action

Abstract

The aims are (a) to determine the mechanism by which neurotensin (NT) enhances prostate Cancer (PC3) cell growth and (b) to test if NT released by eating mediates the cancer- Promoting effects of high fat diets Experiments conducted here show that NT enhanced Arachidonic acid metabolism generating primarily lipoxygenase-derived products NT Stimulated DNA-replication and its effect was blocked by lipoxygenase inhibitors by MAP-kinase inhibitors by PI3 kinase inhibitor, by Ca2+ - channel blocker and by tyrosine Kinase inhibitors. NT caused the accumulation of EGF-like ligand(s) and transactivation Of the EGF receptor.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2002
Accession Number
ADA413288

Entities

People

  • Robert E. Carraway

Organizations

  • University of Massachusetts Medical School

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Culture Techniques
  • Dietary Fats
  • Gastrointestinal Tract
  • Inhibitors
  • Kinases
  • Massachusetts
  • Metabolism
  • Neoplasms
  • Phosphorylation
  • Prostate
  • Prostate Cancer
  • Sugar Phosphates

Fields of Study

  • Biology

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