Control of Alcoholism-Related Folate Deficiency by Regulation of Urinary Folate Excretion

Abstract

Health-related consequences of heavy drinking include nutritional deficiencies. Folate deficiency occurs from multiple causes including increased urinary folate excretion. Ethanol decreases the renal reabsorption of folate leading to increased excretion The main aim of this research is to determine the mechanism by which ethanol decreases folate transport by the kidney. Initially the effects of ethanol on expression of the two renal transport proteins the folate receptor (FR) and the reduced folate carrier (RFc) were determined in vivo and in vitro.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2002
Accession Number
ADA413295

Entities

People

  • Kenneth E. Mcmartin

Organizations

  • Louisiana State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Alcoholism
  • Alcohols
  • Carrier Proteins
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Cirrhosis
  • Confocal Microscopy
  • Culture Techniques
  • Deficiencies
  • Digestive System Processes
  • Medical Personnel
  • Pharmacology
  • Proteins

Fields of Study

  • Medicine

Readers

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