The Molecular Basis of the Response to Radiation
Abstract
This four year Career Development Award with a one year no cost extension has been completed We have made progress towards all three Technical Objectives. Reagents to complete genetic screens were developed in year 1 However, we encountered scientific problems isolating novel cDNAs encoding human homologs of yeast DNA damage response genes RAD9 and DUN1 during year 2 and year 3. In contrast, two hybrid screens resulted in the isolation of human homologs of RAD18 and RAD21 and the focus over years 3, 4 and 5 has been the characterization of the human Rad21 protein in mammalian cells and it's degradation in response to DNA damage.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2002
- Accession Number
- ADA413308
Entities
People
- Sharon E. Plon
Organizations
- Baylor College of Medicine