Fibrosis of the Breast Skin After Irradiation is Reversible and Preventable by Exogenous Decorin

Abstract

Cutaneous fibrosis after breast cancer radiotherapy is unavoidable, progressive, and irreversible. Currently there is no satisfactory, preventive therapy to ameliorate this process. Overexpression of fibrogenic cytokine TGF beta has been associated with soft tissue fibrosis, and reduction of its production or activation can ameliorate radiation induced normal tissue toxicity. Decorin is a small, leucine-rich proteoglycan, and is thought to be a natural inhibitor of TCF beta. In this study, we investigated whether decorin can reduce or prevent radiation induced acute and chronic damage to cutaneous tissue in mouse model. We showed: (1) Inflammatory changes of the papillary dermis in several mouse strains occurred within two weeks of irradiation.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADA413316

Entities

People

  • Ivan Ding
  • Paul Okunieff

Organizations

  • University of Rochester

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Growth Factors
  • Intramuscular Injections
  • Lung Diseases
  • Medical Personnel
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Radiation Oncology
  • Reversible
  • Soft Tissues
  • Therapy
  • Tissues

Fields of Study

  • Biology
  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Immunology and Pathology
  • Trauma Surgery or Emergency Medicine.