Human Prostate Cancer in a Tissue Recombination Model

Abstract

In vivo models based on human epithelial cells (hPrE) will provide powerful tools with which to investigate cancer initiation and progression. Tissue recombinations (TR) composed of hPrE and rat urogenital sinus mesenchyme (rUGM) grafted beneath the renal capsule of immunocompromised rat hosts recapitulate many key events in prostatic development and adult function. The stable integration of known or putative oncogenes into the hPrE component of such TRs is a powerful tool with which to study the effects of these genesin vivo.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2002
Accession Number
ADA413324

Entities

People

  • Karin Williams
  • Simon W. Hayward

Organizations

  • Vanderbilt University Medical Center

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biology
  • Cell Line
  • Cells
  • Culture Techniques
  • Efficiency
  • Electronic Mail
  • Epithelial Cells
  • Eukaryotes
  • Gene Expression
  • Medical Personnel
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Tissue Culture
  • Tissues

Fields of Study

  • Biology

Readers

  • Materials Science.
  • Molecular Biology and Genetics
  • Trauma Surgery or Emergency Medicine.