Progesterone Receptor Isoform Influence on Human Breast Tumor Growth and Hormone Treatment

Abstract

Many postmenopausal women receive progestins in conjunction with estrogens as part of hormone replacement therapy. These women have a slightly higher risk of developing breast cancer than those receiving estrogen alone Progesterone mediates its affects through two known forms of the progesterone receptor, PR-A and PR-B. We aim to study how progesterone, via either PR-A or PR-B, influences estrogen-stimulated tumor formation and growth.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2003
Accession Number
ADA413325

Entities

People

  • Carol A. Sartorius

Organizations

  • University of Colorado Boulder

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Biomolecules
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Chemical Compounds
  • Colorado
  • Diseases And Disorders
  • Estrogens
  • Gene Expression
  • Hormones
  • Neoplasms
  • Progesterone
  • Therapy
  • Xenografts

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biochemistry
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.