Mechanisms and Treatment of Progressive Damage After Traumatic Brain Injury

Abstract

The purpose of this contract is to characterize progressive atrophy associated with long- term behavioral changes after traumatic brain injury (TBI) in the rat. In addition, mechanisms that contribute to this progressive atrophy will be studied in order to determine what appropriate treatment strategies can be designed to target these mechanisms. These studies utilize an established model of TBI that mimics many pathological and behavioral components of human head injury. Due to the chronic outcome measurements of the studies proposed, they are still ongoing. Therefore, no findings from these experiments can be reported yet. However, the initial study on progressive atrophy after TBI has been published. This study demonstrated both gray and white matter atrophy in vulnerable structures following TBI.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2003
Accession Number
ADA413329

Entities

People

  • Helen M. Bramlett

Organizations

  • University of Miami

Tags

DTIC Thesaurus Topics

  • Abnormalities
  • Alzheimer Disease
  • Arteries
  • Brain
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Cerebral Cortex
  • Diseases And Disorders
  • Measurement
  • Medical Personnel
  • Nerve Degeneration
  • Neurodegenerative Diseases
  • Pathology
  • Statistical Analysis
  • Surgery
  • Thalamus

Readers

  • Neurotrauma and Rehabilitation Medicine.