Enabling Technologies for Advanced Soft Tissue Modeling

Abstract

Soft tissue properties represent a major and significant unknown in the domain of medical modeling and simulation. This program presents a 4 year research effort in defining tissue characteristics of three distinct organs - liver, spleen, and kidney- in vivo. Over the course of this program, we will use novel methods of tissue interrogation to characterize non-linear behavior during slow deformations, as would commonly be seen during surgical manipulations. We will then develop mathematical models which can be optimized to permit near real-time representations of organ behaviors, including the boundary characteristics of organs in situ. During this first year, we examined the in vivo deformations of porcine liver using two different instruments, and determined close agreement between the methods. We initiated mathematical models of our experimental measurements. We also established an experimental standard to compare different datasets, and to measure accuracy of mathematical models of tissue properties. These data were not previously known.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2002
Accession Number
ADA413341

Entities

People

  • Robert Howe
  • Steven L. Dawson

Organizations

  • Massachusetts General Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Engineering
  • Computational Science
  • Control Systems
  • Elastic Properties
  • Finite Element Analysis
  • Health Services
  • Image Processing
  • Mathematical Models
  • Measurement
  • Mechanical Engineering
  • Mechanical Properties
  • Mechanics
  • Medical Personnel
  • Modulus Of Elasticity
  • Three Dimensional
  • Virtual Reality
  • X-Ray Computed Tomography

Readers

  • Cardiovascular Physiology
  • Computational Modeling and Simulation
  • Oncology and Biomarker-Based Cancer Detection.