Osteocalcin Promoter-Mediated Expression of Therapeutic Genes in Localized and Metastatic Human Prostate Cancer

Abstract

Osteocalcin (OC) expresses in both normal and cancerous prostate epithelial cells and prostate cancer metastasis to the bone and lymph node. The goal of this research is to develop a novel therapeutic agent(s) based on osteocalcin promoter for the treatment of prostate cancer, particularly bone metastasis. Three therapeutic agents were proposed for testing: thymidine kinase (TK), cytosine deaminase (CD), and Diphtheria toxin interleukin 13 fusion toxin (DT-IL13). Recombinant adenovirus, Ad-OC-TK, carrying TK under the control of mouse OC promoter, with prodrug, has therapeutic efficacy on hormone refractory prostate cancers in animal models and had no toxic side effects in our formal toxicology study.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2002
Accession Number
ADA413350

Entities

People

  • Chinghai Kao

Organizations

  • Indiana University

Tags

DTIC Thesaurus Topics

  • Blood
  • Body Weight
  • Bone And Bones
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Gene Therapy
  • Genetics
  • Medical Personnel
  • Neoplasms
  • Peptide Growth Factors
  • Prostate Cancer
  • Toxicity
  • X-Ray Computed Tomography

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular Genetics
  • Oncology (Cancer Research).