Breast Cancer Susceptibility and DNA Damage/Repair

Abstract

The study is based on breast cancer cases and matched controls from a cohort of women (New York University Women's Health Study-NYUWHS) who have been followed up for 7-13 years since they donated a blood sample and completed a health, lifestyle and dietary questionnaire to determine the incidence of breast cancer The original proposal was to genotype 6 polymorphisms in the genetic pathways for DNA repair or protection against DNA damage in 200 cases and 200 matched controls We expanded the study to 300 cases and 300 controls. For about 40% of subjects we had blood clots or cell aggregates (left after separating out the serum) from which to extract DNA, but for the remainder we had to extract it from the serum. There was abundant DNA in the clots and cell aggregates but much less in the serum.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2002
Accession Number
ADA413358

Entities

People

  • Roy E Shore

Organizations

  • New York University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Blood Coagulation
  • Breast Cancer
  • Classification
  • Health
  • Neoplasms
  • New York
  • Security
  • Universities
  • Women'S Health

Readers

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Technology Areas

  • Biotechnology