Chemistry of Oligonucleotibe-Gold Nanoparticle Conjugates

Abstract

Conjugates prepared by immobilizing thiol-terminated oligonucleotides onto gold nanoparticles from stable colloidal solutions in aqueous media The oligo nucleotides can serve as linkers to organize the gold particles reversibly into three dimensional arrays and the gold particles can function as colorimetric reporters for hybridization of the bound oligomers with target oligonucleotides in solution,

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Mar 15, 2003
Accession Number
ADA413421

Entities

People

  • Chad Mirkin
  • James I. Storhoff
  • Robert C. Mucic
  • Robert Elghanian
  • Robert L. Letsinger

Organizations

  • Northwestern University

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Electron Microscopy
  • Hybridization
  • Materials Science
  • Metallic Nanoparticles
  • Microparticles
  • Nanoparticles
  • Nucleotides
  • Oligomers
  • Particles
  • Self Assembly
  • Spectra
  • Spot Tests
  • Three Dimensional
  • Transmission Electron Microscopy

Fields of Study

  • Chemistry

Readers

  • Electrochemical Surface Science
  • Molecular Genetics
  • Nanocomposite Materials Science

Technology Areas

  • Biotechnology