Design and Synthesis of New Prostate Cancer Chemotherapeutic Agents

Abstract

This proposal is directed towards the development of new chemotherapeutic agents based on the mechanism of action of Taxol(TM). The recent discovery of two other natural products, epothilone, and eleutherobin, which operate by the same unique mechanism of action as Taxol(TM), i.e., microtubule stabilization, provides a unique opportunity for a collaborative approach to the elucidation of the pharmacophore common to these structurally dissimilar substances, using a combination of synthetic and computational studies. Such an advance could lead to the development of a novel family of prostate cancer chemotherapeutics

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2001
Accession Number
ADA413563

Entities

People

  • Jeffrey D. Winkler

Organizations

  • University of Pennsylvania

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical

DTIC Thesaurus Topics

  • Alkanes
  • Alkynes
  • Biological Products
  • Chemical Synthesis
  • Chemistry
  • Chemotherapeutic Agents
  • Cyclic Hydrocarbons
  • Desiccants
  • Films
  • New York
  • Organic Chemistry
  • Prostate Cancer
  • Silica Gels
  • Thin Films

Fields of Study

  • Chemistry

Readers

  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).
  • Systems Analysis and Design