Translational Hyperactivity as a Target for Prostate Cancer

Abstract

This research project strives to advance our understanding of how cell signaling pathways mediated by the protein kinase C (PKC) gene family contribute to the translational hyperactivity that accompanies the unrestrained cell cycle reentry and unlimited replicative potential of prostate cancer cells Experiments designed to address these basic questions are intended to determine the mechanisms regulating the expression of PKC isozymes throughout the progression of prostate cancer and the metabolic consequences of enhanced expression for PKCepsilon (PKCs) Molecular and biochemical approaches are being employed to specifically determine how PKCs activity influences reactivation of the translational repressor protein retinoblastoma (Rb), and thereby global protein synthesis, upon entry into the G1 phase of the cell cycle.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2003
Accession Number
ADA413622

Entities

People

  • David M. Terrian

Organizations

  • East Carolina University

Tags

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Organic Chemistry
  • Peptides
  • Prostate Cancer
  • Proteins
  • Three Dimensional
  • Two Dimensional

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics
  • Prostate Cancer Biology.