Population Based Assessment of MHC Class I Antigens Down Regulation as Markers of Increased Risk for Development and Progression of Breast Cancer From Benign Breast Lesions

Abstract

Despite advances in chemotherapy and radiation therapies, advanced breast cancer still carries a high mortality rate, The need for effective therapies is urgent The overall aim of this research proposal is to recognize early markers of disease and their interaction with other epidemiological risk factors that can serve as risk indicators for subsequent development of breast cancer from precancerous lesions, and as prognostic markers for progression from primary to metastatic disease, The major histocompatibility complex (MHC) class I molecules are found on the cell membrane of all cells in the body and are involved in intercellular communications and in complex interactions with the immune system.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2003
Accession Number
ADA413876

Entities

People

  • Judith Abrams
  • Maria J. Worsham
  • Usha Raju

Organizations

  • Henry Ford Health

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cancer
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Lymphatic Diseases
  • Lymphocytes
  • Medical Personnel
  • Neoplasms

Fields of Study

  • Medicine

Readers

  • Oncology
  • Oncology (Cancer Research).
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.