Developing and Understanding Methods for Large Scale Nonlinear Optimization

Abstract

Our main activity in this grant has been the development and testing of techniques for solving global optimization problems for determining the structure of proteins and polymers. The problem is to find the lowest energy configuration of a protein or other polymer. This problem is a global optimization problem because it has a huge number of local minimizers. In addition, locating the lowest (global) minimizer is very difficult. For proteins, the solution of this problem would represent a solution to the well known protein-folding problem.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2001
Accession Number
ADA413924

Entities

People

  • Richard H. Byrd
  • Robert B. Schnabel

Organizations

  • University of Colorado Boulder

Tags

Communities of Interest

  • Energy and Power Technologies
  • Human Systems

DTIC Thesaurus Topics

  • Abstracts
  • Algorithms
  • Amino Acids
  • Chemistry
  • Computations
  • Computer Programming
  • Computer Science
  • Computer Simulations
  • Computers
  • Convergence
  • Energy
  • Linear Algebra
  • Mathematical Programming
  • Optimization
  • Parallel Computing
  • Parallel Processing
  • Scientists

Readers

  • Oncology
  • Operations Research