HRAD51 Involvement in Genomic Instability and Development of Breast Cancer

Abstract

During the third year of the funded period, we focused on the characterization of interactions between hRAD51 and the five hRAD51 paralogs. We detected strong interactions suggesting a stable complex, and weaker interactions Some of these weaker interaction signals between hRAD51 paralogs increased in the presence of ATP and decreased in the presence of ADP which may indicate a regulatory role for adenosine nucleotides We also continued in our effort to purify the paralogs and heterodimers thereof. Examination of the functional significance of these interactions and the role of adenosine nucleotides is currently in progress.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2002
Accession Number
ADA413939

Entities

People

  • Christoph Schmutte
  • Richard A. Fishel

Organizations

  • Thomas Jefferson University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Adenosine
  • Antibodies
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Chemical Compounds
  • Chemistry
  • Colon Cancer
  • Electronic Mail
  • Escherichia Coli
  • Genomic Instability
  • Ionizing Radiation
  • Neoplasms
  • Nucleotides
  • Precipitation
  • Proteins

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Genetics