Neurofibromatosis Type 2 (NF2) Natural History Consortium
Abstract
Neurofibromatosis 2 (NF2) is an autosomal disorder characterized by the development of multiple tumors within the brain and spinal canal. The purpose of the study is to define the growth rates and clinical course of tumors associated with NF2-affected individuals. An international consortium of clinical centers and expertise in NF2 will be developed, further expanding the infrastructure developed in the "Natural History of Vestibular Schwannomas in NF2" US Army grant. We will standardize the volumetric analysis of intracranial and spinal tumors, assess the patients' audiological, neurological, and ophthalmological functioning, and analyze molecular and clinical features of the disease over the course of 3 years. Currently, 61 subjects are enrolled in the study. Of the subjects that have been scheduled for exams, 85% of GY Year 1 audiological, 100% of cranial MRls, 92% of spinal MRls, 88% of neurological, 92% of ophthalmologic, 81% of SF-36 health surveys and 77% of physical functioning questionnaires have been completed. We have made good progress toward completion of the study's goals and anticipate few problems with the collection of 1 yearYear 2 follow-up data.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2003
- Accession Number
- ADA414115
Entities
People
- William H. Slattery Iii
Organizations
- House Ear Institute