Glutathione Transferase in the Decontamination of O-P Toxins and Chlorinated Hydrocarbons

Abstract

Glutathione transferases are ubiquitous in nature. So far they have been found in all eukaryotes and most bacteria strongly implying they serve an essential function for life. This function appears to be no more than an aid to organisms to detoxify certain chemically active agents that can be toxic. In the housefly Musca domesitica we have been studying the gst gene and its encoded enzyme that is responsible for detoxifying the organophosphotriester neurtoxins (OP) that are used as insecticides. The gene designated gst6a is one of over a dozen found in the organism, has been cloned and expressed in E.coli.

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Document Details

Document Type
Technical Report
Publication Date
Jan 16, 2002
Accession Number
ADA414348

Entities

People

  • Michael Syvanen

Organizations

  • University of California, Davis, School of Medicine

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Bacteria
  • Chemical Compounds
  • Chemistry
  • Chlorinated Hydrocarbons
  • Clones
  • Decontamination
  • Enzymes
  • Eukaryotes
  • Genetics
  • Hydrocarbons
  • Insecticides
  • Microbiology
  • Molecular Biology
  • Molecular Genetics
  • Nucleic Acids
  • Transferases

Readers

  • Marine Ecological Systems Migration
  • Molecular Genetics
  • Molecular and Cellular Biochemistry