Epitope Specific T Cell Immunity to Breast Cancer
Abstract
Studies performed under this grant have made significant contributions to our understanding of the cellular immunity to the HER-2/neu protooncogene which is overexpressed ovarian cancer and a target for immunotherapy. These studies (1) identified novel epitopes recognized by CD4+ cells from patients with both breast and ovarian cancer; (2) characterized the stimulatory ability for CTL induction of previously identified CTL epitopes in both in vitro and in vivo studies in the context of a clinical vaccine study; (3) demonstrated the Thl inducing ability of the epitopes recognized by CD4+ cells in the metastatic lymph nodes of patients with breast cancer; (4) performed a comparative analysis in metastatic and non-metastatic lymph nodes of the Ag-specific response to the CTL and helper epitopes. Most of the results of these studies have been published. In addition, a patent application based on the findings during this granting period has been submitted.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2002
- Accession Number
- ADA414361
Entities
People
- Constantin G. Ioannides
Organizations
- The University of Texas MD Anderson Cancer Center