Prediction of Cellular Dysfunction from Exposure to JP-8
Abstract
During this past 4.5 years, research has been conducted with support from the Air Force Office of Scientific Research. This research has been focused upon assessing the health effects of exposure to jet fuel, JP-8 in military personnel. In addition, research has continued into identifying molecules in exhaled breath that serve as sentinels of exposure, susceptibility and disease. Exhaled breath is composed of many molecules in the gaseous matrix that consists of oxygen, nitrogen, water vapor carbon dioxide and the inert gases. Endogenously produced molecules are present in concentrations that are less than 100 parts per billion (v/v) whereas the concentrations of exogenous molecules are dependent upon the exposure concentration. Another important factor is that the composition of exhaled breath changes throughout the normal breathing cycle. The sources of endogenous molecules in exhaled breath may be systemic tissues or cells found at the alveolar membrane junction, in conducting airway, or in the oral-nasal-pharyngeal cavity. The sources of exogenous molecules in exhaled breath may be from previous or current inspiratory air.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2002
- Accession Number
- ADA414705
Entities
People
- James F. Burdick
- Shelley S. Schnert
- Terence H. Risby
- W. M. Foster
Organizations
- Johns Hopkins University