Genetic Evaluation of Peripheral Nerve Sheath Tumors in Neurofibromatosis Type I
Abstract
The goal of this research project is to identify molecular changes that are associated with the progression of a peripheral nerve sheath tumor (PNST) from benign to malignancy. Archival and prospectively acquired benign PNSTs and malignant PNSTs are collected, and molecular changes at the NF1 locus and throughout the genome are assessed. In addition, immunohistological evaluations of benign plexiform neurofibromas and malignant peripheral nerve sheath tumors are performed. We have begun preliminary analyses of immunohistochemical phenotypes of the tumors and genome-wide screen tetra-nucleotide screen for allelic imbalance, as a marker for accumulation of somatic mutations in PNSTs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2002
- Accession Number
- ADA414769
Entities
People
- David H. Viskochil
Organizations
- University of Utah