Molecular Epidemiology of Breast Cancer: Development and Validation of Acetylation Methods for Carcinogen-DNA Adduct Detection

Abstract

DNA adduct levels in the population as it relates to age, gender, race, and smoking in breast tissues from 235 donors (200 women, 35 men). In order to Molecular epidemiology cam elucidate mew breast cancer risk factors and gene-environment interactions relating to both hormonal and non-hormonal carcinogenic mechanisms. Corroborative epidemiological studies of intermediate biomarkers of carcimogenesis and laboratory studies demonstrating functional importance of the epidemiology findings are needed. The study of carcinogen-DNA adducts can provide corroborative evidence for the importance of genetic susceptibilities in breast cancer risk.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2002
Accession Number
ADA414785

Entities

People

  • Peter G. Shields

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Anhydrides
  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Detection
  • Electronic Mail
  • Epidemiology
  • Genetics
  • Health
  • Laser Induced Fluorescence
  • Liquid Chromatography
  • Mass Spectrometry
  • Mass Spectroscopy
  • Measurement
  • Medical Personnel
  • Neoplasms
  • Spectroscopy

Fields of Study

  • Medicine

Readers

  • Molecular Biology and Genetics
  • Oncology and Biomarker-Based Cancer Detection.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology