The Role of Terbium and Gadolinium in Reversal of Cisplatin Resistance in Cultured Human Breast Cancer Cells
Abstract
This proposal was an innovative endeavor to unravel the intracellular signaling events that occur when terbium ions (Tb3+) or gadolinium ions (Gd3+) are added to cisplatin treatment of cisplatin resistant MDA-MB231 human breast cancer cells Preliminary data demonstrated that either trivalent lanthanide ion reverses the cellular phenotype of microtubules in resistant cells treated with cisplatin alone and mimics the phenotype seen when cisplatin sensitive MDA-MB231 cells are treated with cisplatin These cells (which were treated for 1 hour then allowed to recover for 72 hours) display atypical microtubule organization and do not appear to contain a centrosome.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2001
- Accession Number
- ADA414791
Entities
People
- Ann E. Allworth
Organizations
- Howard University