Centrosome Defects, Genetic Instability and Prostate Cancer

Abstract

Centrosomes are essential organelles that organize mitotic spindles for chromosome segregation and assemble interphase microtubules for controlling cell shape/polarity. All these functions are disrupted in carcinomas, implicating centrosomes in tumorigenesis. We and another group were first to discover that centrosomes were abnormal in most malignant human carcinomas. The work accomplished in this proposal provides evidence for a causative role for centrosomes in prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2003
Accession Number
ADA414841

Entities

People

  • German Pihan
  • Stephen Doxsey

Organizations

  • University of Massachusetts Medical School

Tags

DTIC Thesaurus Topics

  • Cancer
  • Carcinoma
  • Cell Division
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chromosome Aberrations
  • Colon Cancer
  • Cytoskeleton
  • Fungi
  • Genetics
  • Health Services
  • Proteins

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biochemistry
  • Molecular and genetic basis of cancer.
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology