Beta1 and Beta3 Integrins in Prostate Cancer

Abstract

The study of the molecular mechanisms that control cell growth and motility in prostate cancer is an under-investigated area of research, whereas significant progress has recently been made in breast cancer in this field. Members of the Integrin family of cell adhesion receptors, have emerged as crucial regulators of proliferation, migration, intracellular signaling and gene induction The objective of this study was to investigate the effect of target molecules: beta 1 and beta 3 integrins and their downstream signaling pathways on prostate cancer growth and motility. The proposal has highlighted a new approach to the understanding and control of prostate cancer growth and metastatic lesions. Indeed, the PI has been the first to describe a role for beta 1C integrins in prostate cancer cell proliferation and for beta 3 integrins in prostate cancer cell migration. This study has, thus, allowed new target validation in prostate cancer therapy, thus, meeting the goals of the USAMRMC Prostate Cancer Research Program (PCRP).

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2003
Accession Number
ADA414864

Entities

People

  • Lucia R. Languino

Organizations

  • Yale University

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Biomedical And Dental Materials
  • Breast Cancer
  • Cancer
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Epithelial Cells
  • Fish
  • Health Services
  • Liver Diseases
  • Oncology
  • Peptide Growth Factors
  • Peptides
  • Polymeric Films
  • Prostate Cancer

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Prostate Cancer Biology.
  • Research Science/Academic Research