Genetic Risk Factor for Prostate Cancer
Abstract
NKX3.1 is a homeoprotein with prostate-specific expression in adult mammals. NKX3.1 gene targeting studies in mice have shown that the protein is a differentiating factor and suppressor of epithelial cell growth. Importantly, haploinsufficiency in the mice was dominant, suggesting that altered levels of protein could impart a phenotype in humans. We have described a genetic polymorphism, C154T, in 10% of the population that alters the amino acid sequence of the protein from arginine to cysteine at amino acid 52 (R52C).
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2003
- Accession Number
- ADA414867
Entities
People
- Edward P. Gelmann
Organizations
- Georgetown University