An MR Contrast Agent for Intra-Prostatic Imaging of Prostatic Cancer

Abstract

The goal of the research is to develop a magnetic nanoparticle MR contrast targeted to the gastrin releasing peptide receptor (GRP receptor) that will be used to image the intraprostatic distribution of this key molecular marker. Key accomplishments were: (1) synthesis of a variety peptides interaction with the GRP receptor; (2) demonstration the GRP receptor prefers highly soluble positively charged BN-like peptides; (3) preliminary preparation of peptide-nanoparticle conjugates; (4) development of a FITC based assay.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2003
Accession Number
ADA415339

Entities

People

  • Lee Josephson

Organizations

  • Massachusetts General Hospital

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Amino Acids
  • Biomedical Research
  • Chemical Synthesis
  • Chemistry
  • Contrast
  • Electronic Mail
  • Glutamic Acid
  • Hydrophilic Properties
  • Hydrophobic Properties
  • Magnetic Nanoparticles
  • Mass Spectroscopy
  • Metal Oxide Nanoparticles
  • Nanoparticles
  • Neoplasms
  • Prostate Cancer
  • Sequences

Readers

  • Medical Imaging.
  • Molecular and Cellular Biochemistry

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech