Permanent Implantation Brachytherapy for Prostate Cancer Using a Mixture of Radionuclides with Different Half Lives
Abstract
The objective of the project is to test whether the therapeutic effectiveness of permanent implant brachytherapy for prostate cancer can be improved by using a combination of short and long half life radionuclides simultaneously. A theoretical model for continuous low dose rate irradiation using a mixture of radionuclides has been developed. Experiments have been performed using BA1112 tumor cells and Chinese Hamster cells growing in vitro and BA1112 cells growing in vivo as solid tumors in WAG/rij rats. Radiobiology parameters for these cells have been determined and used in the theoretical radiobiology model to improve our understanding of the experimental observations. We have designed and fabricated applicators for in vivo irradiations as well as developed the animal care procedures.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2003
- Accession Number
- ADA415510
Entities
People
- Nath Ravinder
Organizations
- Yale University