Killing Prostate Cancer Cells and Endothelial Cells with a VEGF-Triggered Cell Death Receptor

Abstract

The purpose of this project is to use a novel chimeric cell death receptor (termed VEGFR2Fas) that is triggered by vascular endothelial growth factor (VEGF), as a means to kill prostate cancer cells and vascular endothelial cells. The scope of this project involves: (i) creating adenoviral reagents to express the VEGFR2Fas receptor in prostate cancer cells and endothelial cells; (ii) determining if the VEGFR2Fas receptor kills cells in a VEGF-dependent manner; and (iii) identifying methods for increasing the killing activity of VEGFR2Fas.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2003
Accession Number
ADA415526

Entities

People

  • Timothy P. Quinn

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Adenoviruses
  • Apoptosis
  • Biomedical Research
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Endothelial Cells
  • Growth Factors
  • Infection
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Virion
  • Viruses
  • Wound Infections

Fields of Study

  • Medicine

Readers

  • Oncology (Cancer Research).