Hereditary Breast Cancer: Mutations Within BRCA1 and BRCA2 with Phenotypic Responses

Abstract

From 85 hereditary breast cancer families, 285 invasive breast carcinomas from patients with known BRCA1/2 mutations were analyzed for histo-pathological features, c-erbB2, estrogen receptor (ER) and progesterone receptor (PR) expression This study confirms previous data showing that BRCA1 HBC displays an aggressive biological phenotype characterized by high S-phase fraction and low estrogen and progesterone receptor expression suggesting that BRCA1 breast cancer generally will not respond well to therapy with hormone receptor modulators such as tamoxifen.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADA415553

Entities

People

  • Henry T. Lynch

Organizations

  • Creighton University

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Carcinoma
  • Data Sets
  • Drug Therapy
  • Estrogens
  • Genes
  • Genetics
  • Genomic Instability
  • Hormones
  • Medical Personnel
  • Mutations
  • Neoplasms
  • Phenotypes
  • Progesterone

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics