Structural and Functional Analysis of Androgen Receptor-DNA Interactions

Abstract

Our objective is to use X-ray crystallography to determine the basis for specific interactions between the Androgen receptor and its DNA targets, in order to understand how the receptor can recognize two different bipartite DNA response elements with diametrically opposing arrangements. Our research has now identified a variant of the AR DNA binding domain that yields large, single lattice crystals when bound to a direct repeat response element. These crystals diffract to beyond 3.5 A using home source X-rays and are suitable candidates for solving the structure of the AR dbd-DNA complex. We have thus overcome the significant obstacle in the crystal structure determination. Analysis of the protein-protein and protein-DNA contacts that lead to specific binding could be used to design novel classes of anti-androgens.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2003
Accession Number
ADA415604

Entities

People

  • Daniel T. Gewirth

Organizations

  • Duke University Hospital

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Biomedical And Dental Materials
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Crystal Structure
  • Crystallography
  • Crystals
  • Diffraction
  • Electron Density
  • Electrons
  • Functional Analysis
  • Hormones
  • Hydrogen Bonds
  • Proteins
  • Recognition

Readers

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