Infectivity-Enhanced Adenoviruses for Improved Replicative Oncolysis

Abstract

We have been developing conditionally replicative adenoviral agents (CRADs) for prostate cancer gene therapy. We have sought to improve these agents by increasing their infectivity for tumor targets and by enhancing the specificity of their replication exclusively within tumor targets.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2003
Accession Number
ADA415721

Entities

People

  • David T. Curiel

Organizations

  • University of Alabama

Tags

DTIC Thesaurus Topics

  • Antineoplastic Agents
  • Biological Factors
  • Body Weight
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Genetics
  • Health Services
  • Oncology
  • Peptides
  • Proteins
  • Viruses

Readers

  • Molecular Genetics
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech