A Novel Apoptotic Molecular Bok for the Treatment of Breast Cancer

Abstract

This current proposal is based on previous publications that (1) the proapoptotic Bcl-2 family member Bok, is capable of exerting growth inhibition on cancer cells growing in tissue culture, and (2) the apoptotic activity of Bok is not inhibited by the anti- apoptotic molecules Bcl-2 and Bclx(L). To further investigate the anti-tumor activity of Bok on breast cancer and to develop a Bok gene therapy for breast cancer, we have proposed three specific aims to accomplish our objectives. Specific Aim 1: To confirm hBok-mediated transformation suppression in breast cancer cells. Specific Aim 2: To investigate the mechanisms of hBok-induced apoptosis. Specific Aim 3: To develop a tumor specific promoter using hTERT promoter driven hBok to examine the preclinical effect of hBok for breast cancer gene therapy.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2003
Accession Number
ADA415808

Entities

People

  • Geoffrey Bartholomeusz

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Acids
  • Amino Acids
  • Apoptosis
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Dna Sequence Analysis
  • Endoplasmic Reticulum
  • Gene Therapy
  • Indicator Dyes
  • Lymphocytes
  • Mammary Glands
  • Molecules
  • Neoplasms
  • Programmed Cell Death
  • Proteins

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech