Analysis of Human AXIN2 and Other Wnt Signal Pathway Genes in Human Prostate Cancer
Abstract
Upregulation of cyclin D1, a key regulator of cell cycle, by elevated beta-catenin through the disruption of Wnt signaling pathway is often seen in colon cancer and breast cancer. Cyclin D1 overexpression is also reported in about 25% of human prostate cancer where only about 5% mutation in beta catenin is found. Human AXIN2 and other components in the Wnt signaling pathway may also contribute to cyclin D1 elevation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2003
- Accession Number
- ADA415833
Entities
People
- Xianshu Wang
Organizations
- Mayo Clinic