The Role of Focal Adhesion Kinase and CAS in Integrin-Mediated Signaling on Distinct Forms of Laminin-5

Abstract

This report details final work on this project that was performed while the principal investigator was at University of Nevada Las Vegas. This project has currently been re-defined and the work is being performed at BioForce Nanosciences, Inc. Ames IOWA. The goals of this project were to define signaling pathways triggered in immortalized breast epithelial cells (MCF10A) when these cells bind to and migrate on distinct forms of laminin-5. Activation of FAK and MAPK kinase were shown to occur upon engagement of non- migratory forms of laminin-5 only in the presence of the Beta 1 integrin activating antibody Ts/216.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADA415864

Entities

People

  • Janice L. Huff

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Adhesion
  • Breast Cancer
  • Cell Line
  • Cell Membrane Structures
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Culture Techniques
  • Detection
  • Disease Attributes
  • Integrins
  • Materials
  • Molecules
  • Protein Microarrays
  • Self Assembled Monolayers

Readers

  • Molecular Biology and Genetics
  • Technical Research and Report Writing.