Alpha Synuclein Aggregation in a Neurotoxic Model of Parkinson's Disease

Abstract

The neurotoxin 1-methyl-4-phenyl-tetrahydropyridine (MPTP) inhibits mitochondrial oxidative phosphorylation and replicates the pattern of neuronal neurodegeneration in Parkinson's disease (PD). Neurons that degenerate in PD develop inclusions containing aggregates of a synaptic protein, alpha synuclein. The purpose of this study is to determine how MPTP and other neurotoxins affect cytoskeletal and synaptic proteins and to study the relationship between oxidative damage and synuclein aggregation.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2002
Accession Number
ADA415870

Entities

People

  • Neil W. Kowall

Organizations

  • Boston University

Tags

DTIC Thesaurus Topics

  • Brain
  • Cells
  • Cellular Structures
  • Chemistry
  • Diseases And Disorders
  • Free Radicals
  • Health Services
  • Neurodegeneration
  • Neurodegenerative Diseases
  • Neurons
  • Oxidative Stress
  • Parkinson'S Disease
  • Proteins
  • Synapses

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biochemistry
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Neuroscience