Role of Map Kinase in Mediating the Effects of Vitamin D3 Metabolites on Growth Plate Chondrocytes

Abstract

Endochondral bone formation involves a developmental cascade of cell differentiation and maturation, which culminates in mineralization of the extracellular matrix by chondrocytes. The process is required for normal long bone growth and in certain kinds of bone repair. Vitamin D3 plays an important regulatory role in chondrocyte differentiation and maturation and therefore is essential for proper endochondral ossification. The vitamin D3 family contains two metabolites, 1alpha,25(OH)2D3 and 24R,25(OH)2D3, which have been shown to be active in growth plate cartilage. The actions of these vitamin D3 metabolites are cell maturation-dependent, with lalpha,25(OH)2D3 primarily affecting growth zone chondrocytes and 24R,25(OH)2D3 primarily affecting resting zone chondrocytes. Regulation of endochondral bone formation involves both of these vitamin D3 metabolites.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2003
Accession Number
ADA415952

Entities

People

  • Ehland Haris

Organizations

  • University of Texas Health Science Center at San Antonio

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DTIC Thesaurus Topics

  • Air Force
  • Biological Sciences
  • Bone And Bones
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemical Reactions
  • Chemistry
  • Connective Tissue Cells
  • Culture Techniques
  • Gene Expression
  • Osteogenesis
  • Peptide Growth Factors
  • Polymerase Chain Reaction
  • Proteins
  • Tissues
  • United States

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