Neuroprotective Ganglioside Derivatives
Abstract
In this study, neuroprotective ganglioside derivatives are examined so they can be targeted to specific points in cell death pathways. GM1 ganglioside and several of its chemically modified derivatives are neuroprotective in several neurotoxic models. Here, ganglioside functional groups required for neuroprotection and blood-brain barrier (BBB) permeance are determined Cell death mechanisms are also defined, as are the mechanism(s) by which ganglioside derivatives intervene in the cell death process. In the first year, substantial quantities of GM1 have been isolated and purified.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2002
- Accession Number
- ADA415963
Entities
People
- M. D. Ullman
Organizations
- University of Massachusetts Medical School