Identification of Genes Controlling Mammary Tumor Development and Progression
Abstract
The genes that predispose to breast cancer development in most women with a family history of breast cancer have yet to be identified. We propose a means to identify genes that play a role in cancer development or progression. A mutant allele of the Apc gene results in an increased risk of mammary tumor development in mice. Exposure of mice carrying the mutant allele on one genetic background to a carcinogen results in over 90% of the mice developing carcinomas within 60 days. Another strain of mice carrying the mutant allele are resistant to developing mammary cancer. When these mice are treated with the carcinogen, few develop cancers. However, these mice are still susceptible to the development of hyperplastic, or benign, lesions of the mammary gland. By performing crosses of mutant mice from the susceptible strain with those from the resistant strain, we will determine the chromosomal location of the genes conferring resistance to development of cancer. We will also characterize the changes that occur during the progression from hyperplasia to neoplasia in the mammary lesions that develop in these mice. These studies will be a first step toward the identification of novel genes involved in tumor development and progression.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2003
- Accession Number
- ADA416094
Entities
People
- Amy R. Moser
Organizations
- University of Wisconsin–Madison